Fresh off the bus from Iowa, Joe (Jerry O'Connell) is just trying to make it in New York, but he's got no job, no girl and no place to live. But life changes for Joe as he finds an apartment, along with 50,000 singing, dancing, wisecracking cockroaches. What bugs Joe is how these cockamamie cucarachas meddle with his romance with the lovely Lily. But he'll eye the world of creepy-crawlies differently when the tiny bugsters turn from hindering to helping - like it or not!