Vacation turns to disaster when Houston graduate Kyle and her friends survive a plane crash in the desolate Louisiana Bayou, only to discover there's something infinitely more dangerous lurking in the shallows…a pack of primordial, highly-evolved American alligators.

Apex predators and perfectly adapted to their native habitat, the gators have zeroed in on Kyle and the survivors - pure killing machines 150 million years in the making. And these gators are living in an environment contaminated by illegal chemicals pumped into their ecosystem. They're bigger, smarter, faster, meaner, and hell-bent on devouring anything that stumbles into their territory...